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Research

Research

Research work

 

Price list for services provided by the Republican Scientific Research Unitary Enterprise "Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus" to legal entities, regardless of their form of ownership and subordination, and individual entrepreneurs (see)

 

The cost of services can be calculated individually (A+B+C):

  • A - cost of materials (materials can be provided by the customer)
  • B - the cost of the service (performance of work and provision of services)
  • C - margin, tax (VAT, etc.)

The customer can perform an analysis of pre-prepared material on the basis of the Institute or order the preparation and analysis of the material. The cost of preparing the material is calculated based on the requirements for the material and is agreed by the laboratory employee or the head of the department with the Customer.
 
An exact calculation of the cost of individual services and the regulations for performing research in the laboratory can be obtained from the head of the laboratory or department.

 

Reference Accuracy

Chromato-mass spectrometry is the most accurate method of laboratory and clinical research currently in existence. Several Nobel Prizes have been awarded for scientific research in the field of chromatography or using the chromatographic method. Mass spectrometry is a new level in modern laboratory diagnostics. It allows you to accurately determine the content of the test substance in a particular biological material. This, in turn, helps in making accurate diagnoses.

 

A range of services for the creation of experimental models of pathological conditions

One of the methods for understanding the complex mechanisms of the development of pathological processes in the body is biological modeling. To create models that could be as useful as possible, it is necessary to select one or two essential features that are common to the original and the model. The human body is exposed to physical, chemical, biological, social factors, which in some cases leads to the development of a pathological process or disease. Animal studies allow answering a number of questions regarding triggers, common links in pathogenesis, and the principles of therapy and prevention of a number of diseases. At present, it is possible to reproduce practically any model of pathology under experimental conditions. Let us give some examples of the types of modeling of pathological processes in animals.

 

The employees of the Institute have rich experience in creating various experimental models of pathological conditions:

  • Model of experimental toxic hepatitis. The liver of rats subjected to toxic hepatitis is used for further biochemical, morphological, histological and other studies. The creation of models of pathological conditions in animals also allows us to study the effect of new hepatoprotectors on the processes of regeneration of the liver parenchyma.
  • Model of autoimmune disease .Autoimmune pathology can be characterized as an attack of the immune system against the organs and tissues of the body, resulting in their structural and functional damage. Morphological changes in autoimmune diseases are characterized by inflammatory and degenerative changes in damaged organs. Parenchyma cells show granular dystrophy and necrosis. In the blood vessels, mucoid and fibrinoid swelling and necrosis of their walls, thrombosis are noted, lymphocytic-macrophage and plasmacytic infiltrates are formed around the vessels. In the connective tissue of the stroma of the organs, dystrophy in the form of mucoid and fibrinoid swelling, necrosis and sclerosis are detected. Hyperplasia, intensive infiltration by lymphocytes, macrophages and plasma cells are expressed in the spleen and lymph nodes.
  • Model of experimental oncology. The arsenal of experimental oncology models includes spontaneous, transplantable, and induced animal tumors, human and animal tumor cultures, human tumors inoculated into animals, and molecular genetic models. Spontaneous tumors are found in animals that have not been subjected to any influences from the experimenter. It has been shown that rabbits often develop spontaneous papilloma caused by a DNA-containing virus. It is a benign warty growth on the skin of the ears, which subsequently turns into a malignant tumor that metastasizes to the lungs and lymph nodes. This model has been successfully used to solve the problems of virology and immunology of tumors. Tumors can be induced by various types of radiation, chemical carcinogens, and oncoviruses. Models of animal tumors induced by viruses, as well as models of cells malignantly transformed under the influence of viruses, cultivated in vitro, allowed not only to reveal many secrets of viral carcinogenesis, but also to create a general concept of the molecular mechanisms of tumor formation.
  • other experimental models (on request

 

Available experimental models

  • Models of acute and chronic alcohol intoxication; alcohol withdrawal syndrome; prolonged ethanol anesthesia test; assessment of motor and cognitive functions of rats in the Beam walking test.
  • Models of toxic liver damage (acute, subchronic, chronic), alcoholic and non-alcoholic steatohepatitis; hepatic encephalopathy; cholestasis and biliary cirrhosis (ligation of the bile duct); fibrosis and cirrhosis of the liver;
  • partial hepatectomy).
  • Models of acute hyperlipidemia; alimentary obesity; hypercholesterolemia; atherosclerosis (rabbits).
  • Models of chronic psycho-emotional stress; cold and immobilization stress.
  • Models of physical activity (short-term and long-term running in a treadmill or swimming); endurance exercise.
  • model of myocardial infarction.
  • Models of iodine deficiency, iodine intoxication and hypothyroidism.
  • Models of alloxan and streptozotocin diabetes mellitus.
  • Models of incomplete global ischemia and ischemia-reperfusion of the brain.
  • Modeling of hypercapnic and hypobaric hypoxia in rats and mice. Model of neurodegeneration with the introduction of aluminum chloride and bacterial lipopolysaccharide.
  • Models of vitamin deficiency states (folate, pantothenate, thiamine).
    Perform studies in animal models (mice, rats, rabbits), cell cultures and in vitro.
  • Modeling of chronic inflammation of the lungs.
  • Modeling of acute and chronic inflammation in rats.
    Model for studying the healing of a burn skin wound.
    Mechanical full-thickness wound model

Modeling of pathological conditions in animals helps to find out the etiology, pathogenesis of diseases, methods of treatment and prevention. Biological modeling is also widely used at the preclinical stage in the study of the mechanisms of action of new drugs.

 

Spectral study of microelement balance in the human and animal body based on the analysis of samples of biological tissues

Industry laboratories of the Institute assess the content of chemical elements in the human body for the population and organizations on a paid basis using one of the most modern methods - the method of mass chromatometry.

  • Is the body provided with basic macro- and microelements? Is there a risk of developing microelementoses? How safe is the environment in which you live and work? Are the diets and drugs that a person takes to normalize the balance of microelements and cleanse the body of toxic substances effective?
  • All these questions can be answered by the proposed research methodology.

It is possible to send a hair sample for research by mail (by prior arrangement)!

 

Quantitative analysis of a wide range of natural biologically active compounds in various biological materials

The laboratories of the Institute carry out qualitative identification and quantitative determination of a wide range of natural biologically active compounds (amino acids and their metabolites, water-soluble vitamins, steroid hormones) in various biological materials by high-performance liquid chromatography.

 

Application area:

  • ecology and environmental protection: determination of nitrogen metabolism disorders in living organisms under changing environmental conditions;
  • food industry: quality control and biological value of food products;
  • agriculture: analysis of the biological value and quality of feed, bioadditives, phytochemical analysis of plant materials and agricultural products;
  • medicine: monitoring of the biochemical status of the human and animal body, diagnosis of hereditary enzymopathies, biochemical testing in the field of metabolomics and proteomics of humans and animals;
  • pharmacology: analytical determination of the active substances of drugs and dietary supplements based on amino acids, vitamins and steroid hormones.

Departure on object to the customer for sampling is possible.

 

Advantages:

  • rapid analysis, high quality, reliability, accuracy and reliability of the results, availability and low prices.

 

Information:

Khovanskaya Galina - Deputy Director for Research

phone: +375152314418; e-mail:office@ibiochemistry.by