The Institute is engaged in fundamental and applied research into mechanisms of the pathogenesis of the liver as well as the cardiovascular and endocrine systems and stress so as to develop methods for their prevention, diagnostics and treatment and to design new pharmaceutical products and biologically active additives.
The staff of the Division of Biochemical Pharmacology managed by Prof. V.U. Buko studies medicinal preparations against a wide range of liver pathologies, diabetes mellitus, wound injuries, etc. There were designed and introduced into production such drugs as “Bienosilim” (flavonoids of the holy thisle and bien) and “Ursaklin” (based on ursodeoxycholic acid). Preclinical studies have been carried out of the generic drug “AdeMethionine”.
The Department of Bioregulators (L.I.Nadolnik, Doctor of Sciences., Ph.D) developed the original medicinal agent “Neurovasotropin”, based on lipoic acid, thiamine and pyridoxine, which is indicated for prevention of complications under type 2 and 3 dia-betes. A patent was obtained for a new biologically active additive “Arniacin” for pre-vention of myocardial damages.
A clinical kit was developed for measurement of iodine concentration in biological material and water for assessment of iodine allowances of the body. The sensitivity is 20µg/l, which meets the requirements of the WHO.
The staff of the Division of Natural Biologically Active Compounds has designed the technology for production of drug extracts from medicinal plant raw materials and spicy –aromatic plants to be used in production of biologically active additives, in food industry and perfumery. Products of advanced processing of the extracts for use as analytical standards can be manufactured on a by-order basis.