Alexander V. Tumanov (Candidate of Biological Sciences)

Position: Head of Department

Phone: +375152559087

Mobile: +375333934779

E-mail: shurik00885@gmail.com; office@ibiochemistry.by 

Main areas of activity:

Search for and study of the mechanisms of action of biologically active substances of natural and synthetic origin for the development of new drugs;
Conducting preclinical studies (evaluation of toxicity, teratogenicity, and the impact on the immune system of food products, dietary supplements, feed additives, functional foods, drugs, individual compounds, etc.)
Pharmacology (preclinical studies, pharmacological effects of substances);
Alcohol dependence studies;
Isolation and chemical modification of biologically active substances;
Study of the mechanisms of action of biologically active substances in experimental liver pathologies, diabetes mellitus, and other diseases.

Industry Laboratory Staff

Irina Anatolyevna Kuzmitskaya (Research Associate)
Yulia Vladimirovna Eroshenko (Research Associate)
Anna Valeryanovna Romanchuk (Research Associate)
Anna Ivanovna Marchik (Research Associate)

General Information
The Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus has developed and implemented methods for analyzing biologically active food supplements (BAS) and specialized food products for nutrition in the form of Solid, liquid, and soft forms for the detection of substances.

Analysis Methods
Gas chromatography with mass spectrometric detection;
Liquid chromatography with mass spectrometric detection.

Analysis Procedure
To initiate the analysis of dietary supplements/specialized food products (hereinafter referred to as Samples) at the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus, you must provide: completed analysis application; Information on the composition of the Samples in electronic or hard copy format.

The application must include the full name of the Samples being provided, for example: "Food product...".

Contract Conclusion
After the application and Samples are submitted, an agreement for the analysis is concluded between the Customer and the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus. The cost of the work is determined by the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus separately for each test, depending on the scope and content of the work performed, in accordance with the specifications that form an integral part of the contract. The Customer bears 100% of the costs. Prepayment for work according to the invoice for each test separately.

Sample Requirements
The Customer is responsible for the Samples provided and the accuracy of the information provided.

Samples must be provided by the Customer in unopened manufacturer's packaging, with the original label clearly indicating:

Sample name;
Batch number;
Manufacturing date;
Expiration date;
Composition.

If the Customer provides opened packaging, packaging without a label, or Samples packaged in non-original manufacturer's packaging, they must provide a document certified by the manufacturer or the applicant containing accurate information about the Sample listed above.

Sample Quantity Requirements:

• not less than 30 g for solid Samples;
• not less than 30 ml for liquid Samples.

If the Sample is packaged by the manufacturer in a smaller weight or volume, multiple packages of the Sample must be provided. with a total weight/volume of at least 30 g/30 ml with the same batch (lot) number.

If a Sample has different flavor compositions with the same name, each composition is paid for and analyzed separately, and a separate test report is issued for each Sample.

Analysis Time
Samples are analyzed within 15-30 business days from the date the Customer pays for the testing.

Analysis Results
The analysis results for each Sample are provided to the Customer in the form of a test report. The test results apply only to the Samples submitted by the Customer.

The analysis report may not be used by the Customer for advertising purposes. The report may not be reproduced, distributed, or distributed without the permission of the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus.

Experimental Models

• models of diabetes 1 (alloxan, streptozotocin) and type 2 diabetes (high-fat diet + streptozotocin in low doses);
• models of acute and chronic stress: hypokinesia, hypoxia, psycho-emotional stress, audiogenic stress, physical activity (running), combined stress;
• hypothyroidism model (methimazole-induced, bilateral and unilateral thyroidectomy), iodine deficiency model and excess iodine intake model;
• model of exposure to acute (small, medium, large doses) and chronic ionizing radiation (small, medium doses);
• model of ischemia and ischemia/reperfusion of the kidneys;
• immunodeficiency model;
• pantothenic deficiency model.

Research methods practiced in the laboratory

• determination of the concentration of fat-soluble vitamins by HPLC: A, E, D - in blood serum and animal tissues, food additives, food products, dietary supplements, pharmaceutical substances, etc.;
• determination of the concentration of water-soluble vitamins: - vitamin C (urine and blood), pyridoxine (in the blood);
• riboflavin, thiamine, pyridoxylic acid (in urine) and in other biological materials (blood serum, tissues), as well as milk, food additives, foodstuffs, pharmaceutical substances, dietary supplements, etc.;
• determination of the concentration of hormones by HPLC: - corticosterone, aldosterone, testosterone in blood serum;
• determination of the concentration of coenzyme A and acetyl-CoA by HPLC in animal and human tissues in dietary supplements;
• determination of the concentration of microelements by mass spectrometry with inductively coupled plasma: - water, urine, tissues, food additives, foodstuffs, dietary supplements, etc., animals and humans;
• determination of indicators of the antioxidant system by the spectrophotometric method: - SOD, catalase, GPO, GR, GT; determination of the total antioxidant activity of serum and tissues;
• determination of the concentration of low molecular weight antioxidants (glutathione), as well as the concentration of non-protein, protein thiols and their total in serum and tissues;
• determination of the concentration of LPO indicators: - concentration of TBRS, as well as DPA-reactive products;
• determination of the concentration of free fatty acids in the blood and tissues by gas chromatography.