Grodno, 7 Antoni Tyzenhauz Square
+375152559075
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INSTITUTE OF BIOCHEMISTRY OF BIOLOGICALLY ACTIVE COMPOUNDS

Department of preclinical and experimental research

Nadolnik Liliya Ivanovna

Doctor of Biological Sciences

Position: head of department

Phone: +375152559072

e-mail: lnadolnik@tut.by

Profile in eLibrary

Main activities:

  • study of the mechanisms of violation of the regulation of body weight, carbohydrate metabolism; mechanisms of development of insulin resistance, type 2 diabetes and obesity. Development of methods of prevention and correction;
  • studies of the role of high-calorie diets (high-fat and high-carbohydrate) and chronic stress in the development of obesity, insulin resistance, metabolic syndrome, elucidation of the mechanisms of gender differences;
  • adipose tissue metabolism, endocrine function (white, brown, beige). Browning mechanisms. Possibilities of correction and prospects for the development of drugs for the prevention and treatment of obesity, insulin resistance, type 2 diabetes;
  • study of the role of chronic stress in the disruption of key metabolic systems of the body, the development of neuroprotective, immunoprotective anti-stress drugs, food and feed additives;
  • development of medicines, functional food additives. Study of the mechanisms of action of biologically active substances of natural and synthetic origin for the creation of new drugs. Preclinical studies of drugs - toxicity assessment (acute, subchronic, chronic);
  • creation of medicines, biologically active additives (BAA), functional additives based on plant materials and medicinal plant materials.

 

Main publications (for the last 5 years):

Monographs

  • Nadolnik L.I., Valentyukevich O.I. Free radical processes and the antioxidant system in thyroid hormone deficiency, LAP LAMBERT Academic Publishing 2017, p. 210.

Articles in peer-reviewed journals

  • Blood Cortisol Level in Patients with Metabolic Syndrome and Its Correlation with Parameters of Lipid and Carbohydrate Metabolisms / L. Nadolnik, V. Polubok, K. Gonchar // International Journal of Biochemistry Research & Review. – 2020. Vol. - 29, No. 9. P. 149-158. https://doi.org/10.9734/ijbcrr/2020/v29i
  • Polubok V.Ch. Body weight and glucose metabolism in male and female rats using a high-fat diet and modeling diabetes mellitus: the effects of chronic stress / V.Ch. Polubok, L.I. Nadolnik // Bulletin of the Vitsebsk Dzyarzhaunaga University. - 2020. - No. 4 (109). - S. 46-52.
  • Role of UCP1 Gene Variants in Interethnic Differences in the Development of Cardio-Metabolic Diseases / Flouris AD, Shidlovskii YV, Shaposhnikov AV, A.E. Carrillo, G.S. Metsios, L. Nadolnik, A.Z. Jamurtas, Y. Koutedakis, C. // Front. Genet. – 2017 – Vol: 8, Article 7., P. 1–7doi: 10.3389.
  • Chronic I-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regimen for combating obesity and improving metabolic health / P. Sakellariou, A. Valente, A.E. Carrillo, G.S. Metsios, L. Nadolnik, A.Z. Jamurtas, Y. Koutedakis, C. Boguszewski, C.M. Andrade, P.A. Svensson, N.H. Kawashita, A.D. Flouris // Med Hypotheses. – 2016 – Vol. 93. P. 21–26.

 

Articles in the collections of scientific works

  1. Nadolnik, L. I. Body weight of male and female rats with the use of a high-fat diet and type II diabetes: violation of regulatory mechanisms / L. I. Nadolnik, V. Ch. Polubok, S. V. Lupachik // Collection of articles of the international scientific and practical conference dedicated to the 50th anniversary of the founding of the Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus and the 95th anniversary of the founder of the Institute Academician Ostrovsky Yu.M. "Biologically active substances of natural origin in the regulation of vital processes" - Minsk, 2020. - P. 147-152.
  2. Antidiabetic and hepatoprotective action of homeostasin in an experimental model of type 2 diabetes mellitus / S.V. Lupachik, V.Ch. Polubok, A.V. Tumanov, K.V. Arkhutich, Ya.I. Novogrodskaya, E.G. Badun, L.I. Nadolnik, V.V. Vinogradov // Modern problems of biochemistry and molecular biology: Sat. scientific articles; ed. coll.: I.N. Semenenya [and others]. - Minsk: - Information Center of the Ministry of Finance, 2018.-S. 346-352.
  3. Nadolnik L.I. Prospects for the use of medicinal plants for the prevention and correction of metabolic disorders associated with hyperglycemia and lipid metabolism disorders (metabolic syndrome) / L.I. Nadolnik, V.Ch. Polubok, E.V. Bogdevich, A.V. Tumanov, K.V. Arkhutich, A.V. Shuriberko, S.A. Labor, S.S. Chumachenko, D.A. Goreva, S.V. Lupachik, E.G. Badun, Danga Selenge, G.V. Luzhanin, M.N. M.N. Povydysh, N.A. Narkevich. // Modern problems of biochemistry and molecular biology: Sat. scientific articles; ed. coll.: I.N. Semenenya [i dr.]. - Minsk: - Information Center of the Ministry of Finance, 2018.-S. 383-391.
  4. Problems of iodine supply: deficiency and excess of iodine, provision of some regions of the Grodno region / Nadolnik L.I., Goreva D.A., Lupachik S.V., Chumachenko S.S. – Modern problems of the state and evolution of taxa of the biosphere. M.: GEOKHI RAN (Tr. Biogeochemical Lab.; T. 26), 2017. - P. 150-156., ISBN 978-5-905049-17-0
  5. Non-enzymatic iodination of proteins, posttranslational and oxidative modification of thyroglobulin / Nadolnik L.I., Goreva D.A., Lupachik S.V., Chumachenko S.S. // Biochemistry and molecular biology. Collection of scientific articles, issue 1, - 2017., Belarusian science, pp. 23-38.
  6. Post-translational modifications - possible "fast" regulatory mechanisms for controlling the enzyme activity of cytochrome P450-dependent monooxygenases /A.V. Yantsevich, Ya.V. Dichenko, A.V. Ivanchik, M.V. Shapiro, M. Travkina, L.I. Nadolnik, S.A. Usanov // Biochemistry and molecular biology. Collection of scientific articles, issue 1, - 2017., Belarusian science, pp. 10-22.
  7. Nadolnik L.I. The influence of vitamins and microelements on thyroid function: the effectiveness of iodine deficiency correction / Nutrition and metabolism. Collection of scientific articles. Issue 4., scientific. ed. Moiseenok A.G.; Minsk, Belaruskaya Navuka, 2016, 402 pp., 19.8 ed., circulation 120 copies. pp. 268–286.
  8. Influence of chronic psycho-emotional stress on the structural and functional characteristics of the brain of rats / L.I. Nadolnik, E.M. Doroshenko, A.V. Yantsevich, V.P. Andreev, A.I. Marchik, A.V. Ivanchik, O.A. Tishkevich, S.S. Chumachenko // Modern problems of biochemistry: Sat. scientific Art. At 2 pm / National Academy of Sciences of Belarus [and others]; editorial board: L.I. Nadolnik [i dr.]. - Grodno: YurSaPrint, 2016. Part 1. - P. 238–248.

 

Articles in the materials of international conferences

  1. Nadolnik, L. I. Correction of metabolic disorders in type II diabetes in female and male rats using a complex based on lipoic acid / L. I. Nadolnik, V. Ch. Polubok, S. V. Lupachik [and others]. // Actual problems of biochemistry: a collection of materials of a scientific and practical conference with international participation dedicated to the 60th anniversary of the Department of Biochemistry - Grodno, 2019. - P.225–228.
  2. Nadolnik, L. I. Prevention and correction of metabolic disorders in type II diabetes: drugs based on vitamin-amino acid complexes and extracts of medicinal plants / L. I. Nadolnik, V. Ch. Polubok, E. M. Doroshenko [et al. ] // Collection of materials of the International Scientific and Practical Conference "Belarusian Medicines" - Minsk, 2019. - P. 105–109.
  3. Nadolnik, L.I. Screening studies of the effects of aqueous extracts of medicinal plants: correction of metabolic disorders in type 2 diabetes in rats / L.I. Nadolnik, V.Ch. Polubok, S.V. Lupachik // Collection of materials of the International Scientific and Practical Conference "Belarusian Medicines" - Minsk, 2019. - P. 109-113.
  4. Nadolnik L.I. Influence of uncoupling agents on the function of mitochondria in the brain of rats on the background of the use of a high-calorie diet / L.I. Nadolnik, A.I. Marchik, S.S. Chumachenko // Proceedings of the International Scientific and Practical Conference "Belarusian Medicines" (November 17-18, 2016), editorial board: Usanov S.A. [and etc.]. - Minsk: State Scientific Institution "Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus", 2016. - P. 179-184.
  5. Nadolnik L.I. White, brown, beige: specific features of the functioning of adipocytes; preadipocytes: differentiation, browning / L.I. Nadolnik, A.V. Shuriberko, E.O. Lichik // Modern problems of biochemistry: Sat. scientific Art. At 2 pm / National Academy of Sciences of Belarus [and others]; editorial board: L.I. Nadolnik [i dr.]. - Grodno: YurSaPrint, 2016. Part 1. - P. 249–252.
  6. Nadolnik L.I. Uncoupling effects of fatty acids and other compounds: correction of the metabolism of brown and white adipose tissue / L.I. Nadolnik, A.V. Shuriberko, S.S. Chumachenko // Proceedings of the International Scientific and Practical Conference "Belarusian Medicines" (November 17-18, 2016), editorial board: Usanov S.A. [and etc.]. - Minsk: State Scientific Institution "Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus", 2016. - P. 171-176.
  7. Study of the antioxidant properties of lipoic acid and tyrosine in the in vitro model of oxidative modification of methemoglobin / L.I. Nadolnik, A.V. Tumanov, S.A. Labor, V.V. Vinogradov // Proceedings of the International Scientific and Practical Conference "Belarusian Medicines" (November 17-18, 2016), editorial board: Usanov S.A. [and etc.]. - Minsk: State Scientific Institution "Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus", 2016. - P. 176-179.
  8. Mechanisms of chronic stress in the development of disorders of carbohydrate and lipid metabolism: protective effects of dosed physical activity / L.I. Nadolnik [et al.] // Metabolic syndrome: experiment, clinics, therapy scientific st, / National Academy of Sciences of Belarus; / resp. ed. L.I. Nadolnik. – Grodno, YurSaPrint; 2017. - S. 122-132.
  9. Nadolnik L.I., Polubok V.Ch., Bogdevich E.V. Creation of phytopreparations for the prevention and correction of carbohydrate and lipid metabolism disorders in metabolic syndrome / L.I. Nadolnik, V.Ch. Polubok, E.V. Bogdevich // Metabolic syndrome: experiment, clinic, therapy = Metabolic syndrome: experiment, clinics and therapy: Proceedings of the III International Symposium, Grodno, Republic of Belarus, September 20–22, 2017 / Sat. scientific st, / NAS of Belarus; / resp. ed. L.I. Nadolnik. – Grodno, YurSaPrint; 2017. - S. 180-185.
  10. Development of highly effective and safe pharmaceutical substances based on individual natural compounds for the correction of disorders of fat and carbohydrate metabolism, S.V. Okovity, et al. Metabolic syndrome: experiment, clinics and therapy: Proceedings of the III International Symposium, Grodno, Republic of Belarus, September 20–22, 2017 / Sat. scientific st, / NAS of Belarus; / resp. ed. L.I. Nadolnik. – Grodno, YurSaPrint; 2017. - S. 165-171.
  11. Nadolnik L.I., Shuriberko A.V. Natural activators and inhibitors of the UCP-1 protein: regulation of energy metabolism / L.I. Nadolnik., A.V. Shuriberko // Metabolic syndrome: experiment, clinic, therapy = Metabolic syndrome: experiment, clinics and therapy: Proceedings of the III International Symposium, Grodno, Republic of Belarus, September 20–22, 2017 / Sat. scientific st, / NAS of Belarus; / resp. ed. L.I. Nadolnik. – Grodno, YurSaPrint; 2017. - S. 176-179.
  12. Reactive oxygen species: regulatory effects, mechanisms of cell protection under stress / L.I. Nadolnik, A.V. Shuriberko, O.I. Valentyukevich, D.A. Goreva, A.I. Marchik, S.V. Lupachik, E.O. Lichik, S.S. Chumachenko // Oxygen and free radicals: collection of materials of the International Scientific and Practical Conference (May 19-20, 2016) / ed. ed. V.V. Zinchuk. - Grodno: GrGMU, 2016. - S. 126-128.

 

Abstracts

  1. Liliya Nadolnik, Glucagon-like peptide-1 (GLP-1) as a target for corrections of insulin resistance and type II diabetes / Liliya Nadolnik, Vyacheslav Polubok, Sergei Lupachik and Vladimir Vinogradov // VII International conference on chemistry. Structure and function of biomolecules - Minsk, November. 23-25, 2021 – Book of Abstracts, P. 5, 50.
  2. Influence of low molecular weight antioxidants on the activity of mitochondria and free radical processes in the brain of rats under chronic stress / L.I. Nadolnik, A.V. Shuriberko, A.V. Tumanov, S.V. Lupachik, V.Ch. Polubok, K.V. Arkhutich, S.S. Chumachenko // Modern problems of biochemistry and molecular biology: Sat. scientific articles; ed. coll.: I.N. Semenenya [and others]. - Minsk: - Information Center of the Ministry of Finance, 2018.-S. 391-397.
  3. Neuroprotective effects of dosed physical activity / L.I. Nadolnik, E.M. Doroshenko, A.V. Yantsevich, V.P. Andreev, A.I. Marchik, A.V. Shuriberko, S.S. Chumachenko, S.V. Lupachik // Biochemistry and molecular biology: materials of the 1st Belarusian-Polish-Lithuanian scientific conference “Boundaries of biological sciences. Signaling and metabolism”, dedicated to the 250th anniversary of Academician A. Snyadetsky, Grodno, November 8-9, 2018; ed. coll.: I.N. Semenenya [and others]. - Minsk: - Information Center of the Ministry of Finance, 2018.-Ch. 2.-S. 112-116.
  4. UCP-1: a target for the regulation of energy metabolism and metabolic therapy / L.I. Nadolnik, A.V. Shuriberko, K.V. Arkhutich, A.E. Pravednikova, Yu.V. Shidlovsky // Modern problems of biochemistry and molecular biology: Sat. scientific articles; editorial board: I.N. Semenenya [and others]. - Minsk: - Information Center of the Ministry of Finance, 2018.-S. 397-404.
  5. Neuroprotective effects of fruit body extracts of basidiomycetes / L.I. Nadolnik, E.M. Doroshenko, A.V. Tumanov, V.Ch. Polubok, A.V. Shuriberko, A.I. Marchik, K.V. Arkhutich, E.V. Bogdevich, I.V. Bordok, O.I. Valentyukevich, S.S. Chumachenko // Biochemistry and molecular biology: materials of the 1st Belarusian-Polish-Lithuanian scientific conference “Boundaries of biological sciences. Signaling and metabolism”, dedicated to the 250th anniversary of Academician A. Snyadetsky, Grodno, November 8-9, 2018; ed. coll.: I.N. Semenenya [and others]. - Minsk: - Information Center of the Ministry of Finance, 2018.-Ch. 2.-S. 108-112.
  6. White, brown, beige adipocytes: modern concept of function and biological role / Liliya Nadolnik, Alexey Shuriberko, Evgeny Doroshenko, Alexey Jantsevich, Sergey Chumachenko // The 3rd International Symposium on EuroAsian Biodiversity. . 05-08 July 2017, Minsk - BELARUS. P 47.
  7. The role of chronic stress in the mechanisms of early aging of the body / L.I. Nadolnik, A.V. Shuriberko, A.I. Marchik, E.M. Doroshenko, D.A. Goreva, S.S. Chumachenko // Proceedings of the 2nd Belarusian-Baltic Forum "Cooperation - a catalyst for innovative growth" (October 6-7, 2016). - Minsk: BNTU, 2016. - S. 35-36.
  8. Nadolnik L.I. Influence of external ionizing radiation on iodine metabolism in the thyroid gland of rats: thyroprotective effects of the antioxidant selenium-containing complex / L.I. Nadolnik, D.A. Goreva, S.S. Chumachenko // Proceedings of the International Scientific and Practical Conference "Modern Problems of Radiation Medicine: From Theory to Practice" - Gomel: State Institution "RSPC RMiEC", 2016. - P.63-64.