Grodno, 7 Antoni Tyzenhauz Square
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Department of medical and biological problems of alcoholism

Razvodovsky Yuri Evgenievich

Position: head of department
Phone: +375299435630
e-mail: razvodovsky@tut.by
Google Scholar Profile

Currently, the number of dependent people is increasing all over the world, including in our country. According to the World Health Organization, at the beginning of the 21st century, the abuse of alcohol, drugs and other mind-altering substances has become epidemic. Addictive behavior (from the English addiction - addiction, vicious inclination) is one of the forms of deviant, deviant behavior with the formation of a desire to escape from reality. The presence of addictive behavior indicates a disturbed adaptation to the changed conditions of the micro- and macroenvironment. Traditionally, addictive behavior includes: alcoholism, drug addiction, substance abuse, smoking - chemical addiction, and non-chemical addiction - computer addiction, gambling, love addictions, sexual addictions, workaholism, food addictions (overeating, starvation).
The problem of alcoholism continues to be one of the most socially significant and relevant. This negative phenomenon causes enormous material and moral damage both to society as a whole and to individual citizens. In terms of the scale of their distribution, the magnitude of economic and moral losses, they represent the most serious threat to demographic security, the stability of the development of the state, and the well-being of the nation.

main activities
Development of Means for Metabolic Correction of Consequences of Chronic Alcohol Intoxication
Development of methods for diagnosing chronic alcohol intoxication using biochemical markers
Screening of substances of natural origin as promising agents for the treatment of metabolic disorders
Studies on animal cell cultures (isolation, cultivation, directed differentiation of stem cells, systematic assessment of the biological properties of medicinal substances)
Studies on animal cell cultures (isolation, cultivation, directed differentiation of stem cells, systematic assessment of the biological properties of medicinal substances)

 

                 

 

Material and technical equipment

The structure of the department includes a laboratory for molecular biological research (polymerase chain reaction laboratory, PCR laboratory), a cell culture laboratory, and a biochemical laboratory.


Research methods

spectrophotometric and spectrofluorimetric methods;
analysis of enzyme activity, assessment of substrate concentration, analysis of antioxidant protection;
bioenergy research;
gene expression and protein analysis;
enzyme immunoassay (ELISA);
cell culture testing;
chromato-mass-spectrometric analysis

Scientific research
“Development of modern technologies for diagnosing regimens, duration and duration of alcohol consumption using biochemical markers to solve the problems of expert and medical practice” (SPNI “Translational Medicine”, 2021-2025, subprogram “Experimental Medicine”).
"Development of methods for the metabolic correction of alcoholic cardiomyopathy and comorbidity with plant polyphenols" (SPNI "Translational Medicine", 2021-2025, subprogram "Experimental Medicine").
"Studies of reagent kits for the qualitative detection of the SARS-CoV-2 virus by real-time PCR and determination of the effectiveness of the use of these products for clinical diagnostics."


Dissertation research
Macro- and microelement composition of the heart and blood in alcohol withdrawal syndrome, prevention and correction of its disorders by means of metabolic action.
Amino acid fund of blood plasma, liver and brain in experimental alcohol intoxication and its correction by compositions of L-amino acids.
Functional state of brown adipose tissue mitochondria under stress.

Major Publications

1.Razvodovsky Yu.E. Biochemical markers of alcohol dependence. Narcology. - 2020. - V.19, No. 1. – S. 85–92.
2.Razvodovsky Yu.E., Smirnov V.Yu., Ostrovsky A.A., Semenenya I.N. Effects of amino acid compositions on the amino acid pool of blood plasma in subchronic alcohol intoxication. News of biomedical sciences. - - T.20, No. 2. - S. 97 - 102.
3.Razvodovsky Yu. E. Smirnov V.Yu., Ostrovsky A.A., Semenenya I.N. Effect of amino acid preparations on the amino acid composition of the liver in rats with subchronic alcohol intoxication. The weight. National acad. Sciences of Belarus. Ser. honey. navuk. - 2020. - T. 17, No. 3. - P. 10–15.
4.Zavodnik I., Buko V., Lukivskaya O., Lapshina E., Ilyich T., Belonovskaya E., Kirko S., Naruta E. Kuzmitskaya I., Budryn G., Zyzelewicz D., Orach J., Zakrzeska A. , Kiryukhina L. Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative treatment in vitro. J. Funct. Foods. 2019; 57:83-94.
5.Diesinger T, Lautwein A, Buko V, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Dvorsky R, Buckert D, Bergler S, Renz C, Müller-Enoch D, Wirth T, Haehner T. ω-Imidazolyl -alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis. physiological reports. 2021. 9, N.14795. P.1-20.
6.Buko V., Zavodnik I., Budryn G., Zakłos-Szyda Yub , Belonovskaya E., Kirko S.,. Zyzelewicz D., Zakrzeska A., Bakunovich A., Rusin V., Moroz V. Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis. 2021. Vol.13, N. 4155. P. 1-18.
7.Mundta A.P., Serrib E.R., Siebenforcher M., Alikajd V., Ismayilove F., Razvodovsky Y.E., Hasanovicg M., Marinovh P., Franciskovici T., Cermakovaj P., Harrok J., Sulaberidzel L., Kalapos M.P., Assimov M ., Nurmagambetova S., Ibiship N.F., Molchanova E., Tauber M., Chihais J., Dedovic J., Goseku P., Tataruv N., Golenkov A., Lecic-Tosevski D., Randjelovicy D., Izakovaz L. , Svab V., Vohidova M., Kerimi N., Sukhovii O., Priebe S.. Changes in national rates of psychiatric beds and incarceration in Central Eastern Europe and Central Asia from 1990-2019: A retrospective database analysis. The Lancet Regional Health Europe. 2021. doi.org/10.1016/j.lanepe.2021.100137
8.Razvodovsky YE. Hangover Syndrome: Pathogenesis and Treatment. International Archives of Substance Abuse and Rehabilitation. 2021. Vol.3, N.1. P. 1-5.