The Institute conducts fundamental and applied research aimed at studying the mechanisms of pathogenesis of liver diseases, cardiovascular and endocrine systems, alcohol addiction, stress, in order to develop methods of their prevention, diagnosis and therapy, development of new drugs and biologically active supplements.

The list of completed projects 

In the state register of research and development (R&D) in the order established by the Decree of the President of the Republic of Belarus of 25.05.2006 № 356 "On state registration of research, development and experimental technological works" the works were registered:

1.Task 1.28. "Improvement of bioavailability and bioefficiency of calciferols by combined consumption of functionally related vitamins" GPNI "Fundamental and applied sciences to medicine", subprogram "Translational medicine and pathology", 2019-2020 (No. of state registration: 20190934)

2.Task 1.61. "Correction of the effects of halogenation stress in biosystems using novel spatially shielded pyrocatechin derivatives" GPNI Biotechnology, subprogram "Molecular and Cellular Biotechnology," 2019-2020 (No. of state registration: 20191316)

3.Assignment 5.18. "Research of representatives of classes of fibrates (fenofibrate, besafibrate), thiazolidinediones (pioglitazone) and biguanides (metformin) to reduce alcohol addiction" GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (state registration number: 20190937)

4.Task 5.22. "Development of ways to increase the effectiveness of angiotensin II receptor antagonists in fibrotic and cholestatic liver damage" GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (state registration number: 20190938)

5.Task 5.24 "Study of mechanisms of pleiotropic activity of cholecalciferol and their modulation by riboflavin and menaquin-7"

GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (No. of state registration: 20191838)

6.Task 5.25. "Study of mechanisms of homeostasis protective action in conditions associated with oxidative stress: prevention and correction of complications in diabetes" GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (state registration number: 20190939)

7.Assignment 5.27 "Mechanisms of control of UCP-1 protein uncoupling activity and its role in regulation of energy metabolism" GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (state registration number: 20190936)

8.Assignment 5.28. "Nonenzymatic modification of proteins when exposed to ultraviolet light and ionizing radiation. Protective mechanisms of thiamine and its derivatives" GPNI "Chemical Technologies and Materials", subprogram "Pharmacology and Pharmacy", 2019-2020 (state registration number: 20190935)

BRFFI

1. "Development of a new approach to assessing wound surface readiness for skin graft acceptance" (registration number: 20191840)

2. The action of thiamine and sulbutiamine on the metabolic profile and vitamin B1-dependent processes in rat organs in experimental diabetes mellitus (No. of state registration:20191839)

3. "The use of oxidative stress modulators to enhance the therapeutic effect of traditional anti-tumor drugs" (state registration number:20192255)

Grants of the National Academy of Sciences of Belarus

Bioavailability of cholecalciferol and indexes of mineral exchange in combination with vitamins A and K" (No. of state registration:20191475)

Violations of the mechanisms of neurohumoral regulation in rats on a high-fat and high-carbohydrate diet and their correction using the vitamin-amino acid complex and phytopreparations" (state registration number:20191476)

WORK

1. "The study of the effect of betulin and sesamine additives on the toxic properties of vodka" (state registration number: 20192256)

2. "Development of drugs for the correction of chronic diffuse liver diseases on the basis of individual herbal substances" (state registration number: 20192577)